Gee... ya think so?!?
At the Second International Congress of Psychiatry in Zurich in 1957, Hoch, Pennes, and Cattell (fn 7) raised the question, "What is the reaction of psychotic subjects to drugs which have strong psychological effects or induce psychotic states in normal individuals?" Their answer was, "The majority of schizophrenics displayed intensification of their pre-existing symptomatology on administration of mescaline or LSD 25... The reactions of schizophrenic patients to mescaline and LSD 25 are usually marked with severe anxiety and other emotional patterns, while disorganization of thought and behavior patterns may be profound."
It has been the opinion of some investigators, however, that this disorganization of behavior patterns in schizophrenics might be followed by a reorganization that could be a step toward normalization. Quite recently, Bierer and Browne (fn 8) stated that "We thought this so-called 'disorganization of the psychic integration' must be a temporary removal of the ego-defenses and possibly could be used therapeutically." They decided to combine LSD or LSD plus methamphetamine hydrochloride (Methedrine) with group psychotherapy. Their report on results of treatment of 75 patients, of whom 30 had the diagnosis of schizophrenia or advanced schizoid states, indicated that "burnt out" schizophrenics are among those on whom LSD appears to have no effect. They also state, "Further work is necessary, but it is clear that to include 50% of schizophrenics in a group markedly reduces the chances of success."