This is something they just didn't need...

Minnesota's Red Lake Reservation has had more than its share of tragedies... now add one more to the list:

RED LAKE, Minn. (AP) -- Dozens of trained searchers took to the woods, lakes and air Friday to continue the search for two young brothers who had gone missing two days earlier from the remote Red Lake Indian Reservation in northern Minnesota.

Alicia White - the mother of Tristan Anthony White, 4, and Avery Lee Stately, 2 - appealed for anyone who knows or has seen anything to come forward.

"They were just playing outside the last time I seen them, just playing outside," she told reporters.

The boys disappeared from a yard in a heavily wooded area in the town of Red Lake.

FBI Special Agent Paul McCabe said authorities are trying to determine whether the boys wandered off or foul play was involved. "We don't have any information that would lead us either way," he said.

Tristan has a medical condition that requires medication, and he didn't take it Wednesday morning, White said. He "loves water" and had wandered off before, "but we always found him. This is the first time we didn't find him."

Family members said they were preparing for the worst because it's been cold and searchers have found nothing since the boys disappeared Wednesday. Temperatures reached the mid-40s Friday afternoon and were expected to drop below freezing overnight, according to the National Weather Service.

Prayers are in order, here.